Timothy TPJ Jenkins
I am currently completing a 2-year H.C. Ørsted Postdoctoral Fellowship at the Tropical Pharmacology Lab at DTU. Despite my PhD’s focus on the use of parasitic helminths as novel treatments for autoimmune conditions, especially via gut microbial stimulation, I am now pursuing a different field within biomedicine, i.e. the discovery of toxin targeting antibodies. Specifically, my fellowship's aim is to investigate the potential of alternative antibody scaffolds, i.e. designed ankyrin repeat proteins (DARPins) and nanobodies, as antitoxins. In parallel, I am utilising my bioinformatic training gained throughout my PhD to further improve our antibody discovery pipelines computationally. This includes the high-throughput prediction of toxin structures, identification of target toxin clusters likely to be neutralisable by a single antibody, as well as the prediction of broadly neutralising antibodies via machine learning tools amongst others.
Abstracts this author is presenting:
