Non-front-fanged snakes (NFFS) constitute the majority of living snake species. There is morphological variability of the dentition among NFFS; some components of studied NFFS venoms have notable prey specificity. The medical significance of NFFS is poorly documented, partly because of: limited formal medical review of bitten victims; medically unqualified case recording, and under-emphasis on snakes without known medical importance. Several African (Dispholidus typus, Thelotornis spp.) and Southeast Asian (Rhabdophis tigrinus, R. subminiatus, R. ceylonensis) NFFS have caused life-threatening and/or fatal envenoming featuring hemorrhagic defibrinating coagulopathy, while others e.g., Philodryas olfersii, and Malpolon monspessulanus, have inflicted rare systemic envenoming; others e.g., Boiga irregularis on Guam, have caused clinical effects of uncertain etiology. Bites by most other NFFS species occasionally cause mildly-moderately distressing local effects that may take days, weeks or even months to resolve. Unfortunately, reports describing the clinical effects of bites from other species, even those abundant in some locales, are most frequently single case reports, or low-powered retrospective investigations. Critical consideration of these reports suggests: bites from several dipsadid species (e.g., Helicops, Xenodon) cause mild edema, transient bleeding and erythema with uncommon progressive local edema; while others (e.g., Leptodeira, Boiruna, Heterodon) can infrequently cause more extensive local ecchymoses, progressive edema and occasionally prolonged arthralgia. Although two effective antivenoms have been produced against D. typus and R. tigrinus venoms, their availability, and under some circumstances, their cost, can be prohibitive. Management of hemorrhagic coagulopathic envenoming may include replacement therapy; antifibrinolytics, heparin and several other interventions are contraindicated including routine antibiotic prophylaxis. Local envenoming requires meticulous wound management and supportive therapies; appropriate antibiotics are provided if there is evidence of infection/wound necrosis. Venoms from less than 3% of NFFS species have been studied; investigation of an expanding number of these may provide information important to multiple biomedical and clinical disciplines.