Toxins are entrenched components of ecosystems. Animals are often faced with the challenge to avoid or adapt, and whether they evolve resistance can be a key determinant of their evolutionary trajectory. In this talk I will provide an overview of the diversity of toxin resistance mechanisms present in animals that acquire toxins from their environment. I will then speculate about how toxin resistance, toxin sequestration, and toxin characteristics are interrelated from both ecological and evolutionary perspectives. Finally, I will provide a perspective on the future of toxin resistance research and how it fits in the broader field of toxinology.