Despite their medical importance leading to them being the subject of many studies, the coagulotoxic actions of species within the snake genus Echis (saw scaled vipers) remain poorly elucidated. Using the Stago STA R Max advanced coagulation analysing robotic platform and the TEG 5000 Thromboelastography analyser, we set out to fill these knowledge gaps. Testing across model animal plasmas representing major prey lineages (amphibian, avian, and rodent) and comparing to human, we ascertained that the species most potent on rodent plasma were the most potent to human. Underscoring the fundamental principle that dietary composition and prey specificity may be useful in predicting potential human potency. While the ability of saw scaled viper venoms to activate the blood coagulation factor prothrombin into thrombin is extremely well characterised, the ability to activate other clotting factors has been neglected. Tests for the ability to activate factor X revealed that saw scaled vipers can cause coagulopathy by converting the zymogen of this major blood clotting enzyme into its active form Xa. These results therefore shed new light upon the pathophysiological actions of these extremely medically important snakes, thus providing data essential for evidence-based design of treatment strategies for the envenomed patient. It is hoped that these novel findings pave the way for future studies to investigate the activation of saw scaled viper venoms on other clotting factors, thus establishing a broader understanding of the coagulotoxic capabilities of this medically significant genus.