Blood group antigens represent polymorphic traits inherited among individuals and populations. Blood groups are frequent targets in epidemiological investigations since they are genetically determined traits with known polymorphic expression among individuals and populations. Many blood groups are receptors for toxins, parasites, and bacteria, where they can facilitate colonization or invasion or evade host clearance mechanisms. ABO antibodies can be considered part of the innate immune system against bacterial pathogens and enveloped viruses that carry ABO-active antigens. Existing protocols for antivenom and vaccine treatment are generally not well optimized due partly to inadequate knowledge of the toxicokinetics of venoms in patients with different blood types. Our results suggest that both the severity of envenomation and the antivenom efficacy for humans could be defined also by the blood group of the patient. Current investigation devoted to the influence of crude snake venom and its active components (PLA2, metalloproteinases, and serine proteases) on the human red blood cells of ABO-groups. A number of biophysical and biochemical methods were used to determine the specificity of the viper venom action on the erythrocytes of different blood groups.