Lunasin is a soy peptide with a range of bioactivities including cytotoxicity and has potential in the treatment of cancer and obesity related diseases. Although the peptide is only 43 residues in length, it contains three regions with different proposed activities/functions and appears to have oral bioavailability, albeit in the presence of other proteins. The full-length peptide has an effect on inflammatory cytokines. Here we have analysed truncated forms of lunasin and their effects on inflammatory cytokine suppression with the aim of developing novel anti-inflammatory drugs.